Tulsimer® Ploymer in a fine mesh form, find a number of uses in the biotechnology arena. Micro carriers in cell culture synthesis, synthesis of peptides are two of the many applications where these polymers have been used.

In the cell cutlture synthesis, Tulsimer® PMS polymers are used in preparation of micro-carriers used for propgation of Anocharge Dependant Cells ADCs, in turn find applicaitns as substrates for production of biological products for human and vetinary use (viral vaccines, B-interferon and hormones). PMS polymers can be tailor-made to meet the needs of the individual application.

Tulsimer® CMB polymers used for peptide synthesis have cholomethyl functionality. Use of these types of materials for synthesis of peptides was initiated by Merrifield in 1963. The formation of peptide bond starts with reaction of a protected amino acid molecule (generally protected using ter-butoxy carbonyl) with chloromethyl group on the surface of the polystyrene polymer. After removal of the protecting group, a new amino acis molecule is reacted to elongate the peptide chain. The elongation is continued with stepwise addition. Excess reagents and byproducts are removed by filtration at each step. The final step in the synthesis involves freeing up of the protecting group as well as liberating the peptide from the polymer. Properties of the polymers that are critical for successful synthesis are: bead size, swelling of the beads on variety of solvents anf extent of chloromethylation. Tulsimer® CMB polymers can be tailor-made to meet the needs of the individual application.

Tulsimer® CMB polymers used in these technologically demanding applications are custom synthesized to suit individual application needs. They are made under very carefully controlled conditions using strictest quality standards.